Abstract P065: A Novel Risk Score For The Progression Of Carotid Plaque In The Japanese Community: The Suita Study

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-09, Vol.76 (Suppl_1)
• Main Authors: Kokubo, Yoshihiro, Watanabe, Makoto, Higashiyama, Aya, Nakao, Yoko, Honda-Kohmo, Kyoko, Miyamoto, Yoshihiro
• Format: Article
• Language: English
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.76.suppl_1.P065

Abstract only Purpose: We have first reported that the new progression of carotid artery plaque (Prog-PQ) is a risk factor for incident cardiovascular disease (CVD), but the Prog-PQ risk score has not been established. Methods: We studied 4,724 Japanese (mean age 59.7 years) without CVD, whose intima-media thickness (IMT) was measured with carotid ultrasonography on both sides of the entire carotid artery areas as a baseline survey (April 1994 to August 2001). We defined carotid plaque as a maximum IMT of the common carotid artery >1.1mm. We excluded subjects with carotid plaque at baseline (n=1,044), lost to follow-up (n=167), and missing data (n=2). For 3,511 subjects, carotid ultrasonographic follow-ups were performed every two years until March 2016. Blood pressures (BPs) were used the average of two measurements recorded more than 1 min apart. Cox proportional hazard ratios were analyzed after adjusting for cardiovascular risk factors. We used the area under the receiver operating characteristic curve to evaluate the model's discrimination. Results: During 38,454 person-years of follow-up, 1,771 instances of the Prog-PQ occurred. Compared to subjects with systolic BP (SBP)