Abstract 093: Association Of Preterm Birth And Low Birth Weight With The Circulatory And Urinary Renin-angiotensin System In Youth With Newly Diagnosed Primary Hypertension

Abstract only Background: While the RAS is altered in youth born preterm and may play a role in development of HTN, this has not been investigated in youth with primary HTN. We hypothesized that lower gestational age (GA) and lower birth weight (BW) would be associated with higher Ang II, lower Ang-...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2022-09, Vol.79 (Suppl_1)
Main Authors: Vincent, Carol, Chen, Ashton, South, Andrew M
Format: Article
Language:English
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Summary:Abstract only Background: While the RAS is altered in youth born preterm and may play a role in development of HTN, this has not been investigated in youth with primary HTN. We hypothesized that lower gestational age (GA) and lower birth weight (BW) would be associated with higher Ang II, lower Ang-(1-7), and higher Ang II/Ang-(1-7) in plasma and urine. Methods: This is a secondary analysis of baseline data from a pilot prospective cohort study of 30 youth aged 5-17 years with newly diagnosed primary HTN per national guidelines. Exclusion criteria were heart or chronic kidney disease and diabetes mellitus. Exposures were GA, BW, and BW z-score on the continuous scale and as binary variables, preterm birth (GA
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.79.suppl_1.093