Abstract 097: Sexually Dimorphic Transcriptional Phenotypes In Tubular Epithelial Cells Of The Rat Kidney

Abstract only Sexual dimorphism is a key biological variable in different organ systems. Although a growing body of evidence at single cell-resolution highlights sex differences in the kidneys of humans and mice, information regarding rats is limited. We integrated publicly available datasets to con...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2023-09, Vol.80 (Suppl_1)
Main Authors: Kramer, Benjamin K, Zhang, Ronghao, Gonzalez-Vicente, Agustin
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only Sexual dimorphism is a key biological variable in different organ systems. Although a growing body of evidence at single cell-resolution highlights sex differences in the kidneys of humans and mice, information regarding rats is limited. We integrated publicly available datasets to construct a single-cell RNA sequencing atlas of the rat kidney, incorporating data from 3 females and 3 males. Transcriptomes from the tubular epithelial cell clusters, exhibited strong correlation with those from rat-kidney microdissected tubule segments and single-cell RNA sequencing of human kidney biopsies. We hypothesize that transcriptomes of rat tubular epithelial cells present sexual dimorphism. To test this hypothesis, we identified genes that were differentially expressed between sexes (DEGs: log2FC >= 1; adjusted-p
ISSN:0194-911X
1524-4563
DOI:10.1161/hyp.80.suppl_1.097