Abstract P175: Selective Regional Injections of Alginate Hydrogel into Cardiac Veins Improve Left Ventricular Function and Reverse Chamber Remodeling in Dogs with Chronic Heart Failure

Abstract only Background: Progressive LV enlargement and dysfunction are characteristics of heart failure (HF) and are associated with increased mortality and morbidity. We tested the hypothesis that selective regional injections of alginate hydrogel implants (AHI, Algisyl-LVR, Lonestar Heart, Inc.)...

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Bibliographic Details
Published in:Circulation research 2011-12, Vol.109 (suppl_1)
Main Authors: Sabbah, Hani N, Wang, Mengjun, Sabbah, Michael S, Rastogi, Sharad, Gupta, Ramesh C, Helgerson, Sam
Format: Article
Language:English
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Summary:Abstract only Background: Progressive LV enlargement and dysfunction are characteristics of heart failure (HF) and are associated with increased mortality and morbidity. We tested the hypothesis that selective regional injections of alginate hydrogel implants (AHI, Algisyl-LVR, Lonestar Heart, Inc.) into isolated segments of epicardial veins of the failing LV will increase LV wall thickness and lead to reduced LV size, lower LV wall stress and improved LV systolic and diastolic function. Methods: 12 dogs with coronary microembolization-induced HF (LV ejection fraction, EF
ISSN:0009-7330
1524-4571
DOI:10.1161/res.109.suppl_1.AP175