Abstract 002: Blinded Head-to-Head Comparison of Intracoronary Allogeneic Cardiosphere-Derived Cells (icCDCs) Versus Allogeneic Mesenchymal Stem Cells (icMSCs) in Swine with Hibernating Myocardium

• Published in: Circulation research 2013-08, Vol.113 (suppl_1)
• Main Authors: Weil, Brian R, Suzuki, Gen, Leiker, Merced M, Fallavollita, James A, Canty, John M
• Format: Article
• Language: English
• ISSN: 0009-7330; 1524-4571
• DOI: 10.1161/res.113.suppl_1.A002

Abstract only Background: Autologous icCDCs and icMSCs each improve myocardial function by stimulating endogenous myocyte proliferation. Since few myocytes arise directly from the injected cells, we evaluated the feasibility and comparative efficacy of allogeneic icCDCs vs. icMSCs. Methods: Studies were conducted in a blinded fashion. Immunosuppressed swine (cyclosporine 200 mg/day, N=26) with hibernating myocardium from a chronic LAD stenosis were randomized to receive vehicle, ~35 x 10 6 icMSCs, or ~35 x 10 6 icCDCs. Cells were infused into the 3 major coronary arteries at ~10 6 cells/min under continuous flow conditions. LAD function and pathologic indices of myocyte regeneration and proliferation were assessed 1 month later. Results: Baseline LAD wall thickening (%WT) was reduced in all animals (LAD 38 ± 2% vs. 83 ± 5% in remote, p