Abstract 400: Regulated Levels of Sarcolemmal Membrane Protein Isoform 3 Impact Cardiac Function in Mice

Abstract only The sarcolemmal membrane-associated proteins (SLMAPs) are a family of tail-anchored membrane proteins generated by alternative splicing of the SLMAP gene. A ubiquitously expressed SLMAP isoform 3 encompasses an N-terminal FHA domain with extended coiled-coil structure and has been impl...

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Bibliographic Details
Published in:Circulation research 2015-07, Vol.117 (suppl_1)
Main Authors: Mlynarova, Jana, Trentin-Sonoda, Mayra, Salih, Maysoon, Gaisler da Silva, Fernanda, Major, Jennifer L, Sorelli Carneiro-Ramos, Marcela, Tuana, Balwant S
Format: Article
Language:English
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Summary:Abstract only The sarcolemmal membrane-associated proteins (SLMAPs) are a family of tail-anchored membrane proteins generated by alternative splicing of the SLMAP gene. A ubiquitously expressed SLMAP isoform 3 encompasses an N-terminal FHA domain with extended coiled-coil structure and has been implicated in cell cycle control. Heart function in transgenic mice with cardiac-specific overexpression of SLMAP3 cDNA driven by α myosin heavy chain promoter was evaluated by echocardiography. qPCR and western blot were used to analyze gene and protein expression respectively. Structure and fibrosis was analyzed by H&E and Masson’s Trichrome staining. Function analysis showed a 15% (p
ISSN:0009-7330
1524-4571
DOI:10.1161/res.117.suppl_1.400