Abstract P390: Gender And Strain Background Affect Cardiopulmonary Function In Col4a3-/- Alport Mice

BackgroundAlport syndrome (AS) is a hereditary form of chronic kidney inflammation that results in renal failure (RF). Our group previously reported that Col4a3-/- mice, a model of AS and RF, on 129J background exemplified multiple features of heart failure with preserved ejection fraction (HFpEF)....

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Bibliographic Details
Published in:Circulation research 2021-09, Vol.129 (Suppl_1), p.AP390-AP390
Main Authors: Iansen Irion, Camila, Williams, Monique, Eisenberg, Trevor, Seo, Grace, Lambert, Guerline, Takeuchi, Lauro M, Young, Karen C, Hare, Joshua M, Shehadeh, Lina A
Format: Article
Language:English
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Summary:BackgroundAlport syndrome (AS) is a hereditary form of chronic kidney inflammation that results in renal failure (RF). Our group previously reported that Col4a3-/- mice, a model of AS and RF, on 129J background exemplified multiple features of heart failure with preserved ejection fraction (HFpEF). This study investigates the effect of 3 different genetic backgrounds on cardiopulmonary function in Col4a3-/- mice. MethodsMale and female Col4a3-/- (Alport) and WT mice on 3 different genetic backgrounds, 129x1/SvJ, C57Bl/6 and BALBC, were examined using echocardiography, whole body plethysmography (WBP) and pressure-volume (PV) loop analysis. Ttest was used for statistical analysis. Four groups per strain were used (n= 4 to 15 per group). ResultsCompared with their respective age-matched WT controls, both male and female 8-week-old Col4a3-/- 129x1/SvJ mice demonstrated impaired systolic function (EF of 56% to 43.7%, p=0.0018 for females and 50.9% to 42% for males, p=0.044; SV, CO, p
ISSN:0009-7330
1524-4571
DOI:10.1161/res.129.suppl_1.P390