Abstract P1176: What Is The Nature Of The Hypertrophic Response Contributing To Pregnancy-induced Cardiac Growth And Its Reversal?

Abstract only During pregnancy, the maternal heart undergoes physiological cardiac growth, reversing following parturition; however, the contributing underlying processes are largely unknown. Changes in cardiac metabolism appear to be associated with cardiac growth through a reduction in glucose cat...

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Bibliographic Details
Published in:Circulation research 2023-08, Vol.133 (Suppl_1)
Main Authors: Collins, Helen E, Schulman, Emily
Format: Article
Language:English
Online Access:Get full text
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Summary:Abstract only During pregnancy, the maternal heart undergoes physiological cardiac growth, reversing following parturition; however, the contributing underlying processes are largely unknown. Changes in cardiac metabolism appear to be associated with cardiac growth through a reduction in glucose catabolism. We have also shown that several cardiac metabolic transcripts, proteins, and liver-derived metabolites that are elevated during pregnancy are associated with cardiac growth. However, the nature of the hypertrophic response observed in the maternal heart is unclear. Therefore, this study aimed to examine the metabolic and hypertrophic changes associated with pregnancy-induced cardiac growth and reversal. Studies revealed that both heart weight (HW: TL; p < 0.0001) and liver weight (LIV: TL; p
ISSN:0009-7330
1524-4571
DOI:10.1161/res.133.suppl_1.P1176