Abstract 3013: Cerebral Perfusion Parameter Differences in Clinically Relevant Categories of Carotid Stenosis/Occlusion

Abstract only Hypothesis: To determine whether clinically relevant categories of carotid stenosis are associated with changes in cerebral blood flow. Methods: We examined a consecutive cohort of stroke patients with confirmed stroke on DWI imaging who underwent CT angiography (CTA) and perfusion CT...

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Published in:Stroke (1970) 2012-02, Vol.43 (suppl_1)
Main Authors: Kung, Nancy T, Jain, Anunaya, Jain, Minal, Kanthala, Abhijit R, Jahromi, Babak S
Format: Article
Language:English
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Summary:Abstract only Hypothesis: To determine whether clinically relevant categories of carotid stenosis are associated with changes in cerebral blood flow. Methods: We examined a consecutive cohort of stroke patients with confirmed stroke on DWI imaging who underwent CT angiography (CTA) and perfusion CT imaging on presentation with acute symptoms. Degree of carotid stenosis was measured per NASCET criteria on CTA. Perfusion CT was analyzed to calculate relative mean transit time (rMTT), relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) of normal brain tissue ipsilateral to carotid disease. Measurements excluded areas of infarction to avoid confounding hemispheric perfusion changes with local changes due to distal cerebral artery occlusion(s), and subjects with MCA occlusions on any side were excluded. Results: The cohort consisted of 119 patients. Of these 8.4% had 100% ipsilateral carotid occlusion, 1.7% had near-occlusion, 5% had 70-99% stenosis, 5.9% had 50-69% stenosis, and 79% had
ISSN:0039-2499
1524-4628
DOI:10.1161/str.43.suppl_1.A3013