Abstract TMP36: Persistent Stroke-induced Sensory, Motor And Cognitive Deficits Involve Long-term Myelin Loss In Major Fiber Tracts

Abstract only Objectives: Persistent neurobehavioral deficits and brain changes need validation for future brain restoration research. Here neurological and brain changes were determined post-stroke for this purpose. Methods: Two hr middle cerebral artery occlusion (tMCAO) or sham (Sham) surgery was...

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Bibliographic Details
Published in:Stroke (1970) 2013-02, Vol.44 (suppl_1)
Main Authors: Rosenbaum, Daniel M, Zhou, Jin, Zhuang, Jian, Li, Jie, Ooi, Evelyn, Bloom, Jonathan, Poon, Carrie, Lax, Daniel, Barone, Frank C
Format: Article
Language:English
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Summary:Abstract only Objectives: Persistent neurobehavioral deficits and brain changes need validation for future brain restoration research. Here neurological and brain changes were determined post-stroke for this purpose. Methods: Two hr middle cerebral artery occlusion (tMCAO) or sham (Sham) surgery was performed in male SD rats. Measurements made over 10 weeks included: (1) sensory, motor, beam balance, hindlimb and forepaw behaviors, and (2) complex active place avoidance learning (APA) and simple passive avoidance retention (PA). Electroretinogram (ERG) was measured at term. Measurements of hemispheric loss (infarction), hippocampus CA1 neuronal loss and myelin (Luxol Fast Blue) staining in several fiber tracts were made. Results: Compared to Sham, tMCAO produced significant but acute deficits in forelimb foot fault for only 1 day (max 2144 ± 556 % change, p
ISSN:0039-2499
1524-4628
DOI:10.1161/str.44.suppl_1.ATMP36