Abstract TP438: Nanoparticulate Matter Exposure Mediates White Matter Changes in a Murine Model

Abstract only Background: Clinical and epidemiologic studies suggest a relationship between long-term nano-particulate matter (nPM) exposure and white matter injury 1 . Accumulating laboratory evidence suggests that nPM exposure causes inflammation in multiple brain regions 2 . Objective: We sought...

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Bibliographic Details
Published in:Stroke (1970) 2017-02, Vol.48 (suppl_1)
Main Authors: Babadjouni, Robin, Liu, Qinghai, Cheng, Hank, Durazo, Ramon, Hodis, Drew M, Patel, Arati, Radwanski, Ryan, Sioutas, Constantinos, Morgan, Todd E, Finch, Caleb E, Mack, William J
Format: Article
Language:English
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Summary:Abstract only Background: Clinical and epidemiologic studies suggest a relationship between long-term nano-particulate matter (nPM) exposure and white matter injury 1 . Accumulating laboratory evidence suggests that nPM exposure causes inflammation in multiple brain regions 2 . Objective: We sought to study the effects nano-particulate matter exposure on microglia activation and complement upregulation within the corpus callosum in a murine model. Methods: C57 black 6J mice were randomized to re-aerosolized nPM (n=18, nPM
ISSN:0039-2499
1524-4628
DOI:10.1161/str.48.suppl_1.tp438