Abstract WP62: Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy

Abstract only Introduction: Multiple studies have correlated larger final infarct volume (FIV) with worse clinical outcomes. In INTERRSeCT , an international multicenter prospective cohort study, we sought to determine the favorable intracranial clot characteristics predicting smaller infarct volume...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2018-01, Vol.49 (Suppl_1)
Main Authors: Al Sultan, Abdulaziz S, Al-Ajlan, Fahad S, Najm, Mohammed, Casault, Colin, Neweduk, Anneliese, Horn, MacKenzie, Field, Thalia S, Puig, Josep, Castellanos, Mar, Dowlatshahi, Dar, Sohn, Sung-II, Ahn, Seong H, Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Boulanger, Jean-Martin, Asil, Talip, Calleja, Ana I, Goyal, Mayank, Hill, Michael D, Demchuk, Andrew M, Menon, Bijoy K
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract only Introduction: Multiple studies have correlated larger final infarct volume (FIV) with worse clinical outcomes. In INTERRSeCT , an international multicenter prospective cohort study, we sought to determine the favorable intracranial clot characteristics predicting smaller infarct volumes. Methods: FIV was measured (24 ±12 hours after baseline imaging) in 605 patients from INTERRSeCT study by blinded readers using Quantomo (Cybertrial Inc, Calgary). Clot Burden Score (CBS) is a 10-point scale with 10 referring to a completely patent ipsilateral anterior circulation from ICA to both M2 arteries, whereas 0 refers to a completely occluded ipsilateral anterior circulation. Residual Flow Grade (RFG) assesses the radiological permeability of the clot to contrast, with grade 0, 1, and 2 defined as no contrast, diffuse ghosting, and hairline lumen, respectively. Both of these scores were assessed by a blinded reader to the FIV. Using ordinal logistic regression, FIV was divided into deciles as the outcome. CBS and RFG were analyzed from 0 to 10, and 0 to 2, respectively. Two models were used, the first has no recanalization status, while the second included it. Results: The median FIVs with and without recanalization were 12.34 ml (IQR: 32.3 ml) and 22.15 ml (IQR: 60.12ml), respectively. CBS and RFG were independently predictive of FIV (p-value=
ISSN:0039-2499
1524-4628
DOI:10.1161/str.49.suppl_1.WP62