Cell Growth on In Situ Photo-Cross-Linked Electrospun Acrylated Cellulose Acetate Butyrate

In this study, electrospinning was combined with UV curing technology for producing in situ photo cross-linked fibers from methacrylated cellulose acetate butyrate (CABIEM). ECV304 and 3T3 cells were seeded on electrospun fibrous scaffolds. Collagen modified CABIEM fibers were also prepared for impr...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2012-01, Vol.23 (7), p.887-899
Main Authors: Çakmakçı, Emrah, Güngör, Atilla, Kayaman-Apohan, Nilhan, Kuruca, Serap Erdem, Çetin, Muzaffer Beyza, Dar, Kadriye Akgün
Format: Article
Language:English
Subjects:
CELL LINES
CELLULOSE
ELECTROSPINNING
TISSUE ENGINEERING
UV CURING
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Summary:In this study, electrospinning was combined with UV curing technology for producing in situ photo cross-linked fibers from methacrylated cellulose acetate butyrate (CABIEM). ECV304 and 3T3 cells were seeded on electrospun fibrous scaffolds. Collagen modified CABIEM fibers were also prepared for improving cell adhesion and proliferation. Cross-linking and the morphology of the fibers were characterized by ATR-FTIR spectrometry and environmental scanning electron microscopy (ESEM). The cytotoxicity of the fibers was examined using the MTT cytotoxicity assay. According to the results, electrospun fibrous scaffolds are non-toxic and cell viability depends on the amount of collagen. It was found that cell adhesion and cell growth were enhanced as the collagen percentage was increased.
ISSN:0920-5063
1568-5624
DOI:10.1163/092050611X566135