Microscale three-dimensional polymeric platforms for in vitro cell culture systems

This paper describes fabrication schemes to create multidimensional polymeric platforms to study cell function. A key feature of these constructs is the replication of in vivo geometry and dimensional size scales that will aid in the understanding of fundamental cell-environment interactions. Advant...

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Bibliographic Details
Published in:Journal of biomaterials science. Polymer ed. 2001-01, Vol.12 (8), p.921-932
Main Authors: Snyder, Jennifer Deutsch, Desai, Tejal Ashwin
Format: Article
Language:English
Subjects:
Animals
Biocompatible Materials - chemistry
CELL CULTURE
Cell Culture Techniques - instrumentation
Cell Culture Techniques - methods
Fibroblasts - cytology
Heart - physiology
MICROFABRICATED
MICROTOPOGRAPHY
Myocardium - cytology
POLYMER
Polymers
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Summary:This paper describes fabrication schemes to create multidimensional polymeric platforms to study cell function. A key feature of these constructs is the replication of in vivo geometry and dimensional size scales that will aid in the understanding of fundamental cell-environment interactions. Advantages of these microtextured membranes include the high degree of reproducibility, optical clarity, and the ability to create multiple features on the micron and sub-micron size scale. We have demonstrated the creation of controlled microscale features on hydrogels as well as biodegradable materials such as poly(lactic-glycolic acid). These microtopographies selectively degrade under physiological conditions. Because of the flexibility of substrate material and the ease of creating micron size structures, this technique can be applied to a multitude of physiological and biological systems.
ISSN:0920-5063
1568-5624
DOI:10.1163/156856201753113105