The Role of Fibrinolysis in the Therapy of Peripheral Vascular Disease

In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxify...

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Bibliographic Details
Published in:Angiology 1984-07, Vol.35 (7), p.436-442
Main Authors: Ambrus, Clara M., Ambrus, Julian L., Gastpar, Helmuth, Sharma, Satya D., Suh, O.W., Moore, Robert H., Williams, Phyllis
Format: Article
Language:English
Subjects:
Alprostadil
Animals
Arterial Occlusive Diseases - drug therapy
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Drug Synergism
Fibrinolysin - therapeutic use
Fibrinolysis - drug effects
Macaca
Male
Medical sciences
Pentoxifylline - therapeutic use
Pharmacology. Drug treatments
Prostaglandins E - therapeutic use
Urokinase-Type Plasminogen Activator - therapeutic use
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Summary:In vivo thrombolytic studies in stumptailed monkeys indicated that pentoxifylline potentiates thrombolysis induced by urokinase activated human plasmin. Pentoxifylline as well as prostaglandin E1 released plasminogen activators and activated the fibrinolysin system. From this point of view pentoxifylline and prostaglandin E1 synergized with each other. Pentoxifylline potentiated the thrombolytic effect of prostaglandin E1 in vivo.
ISSN:0003-3197
1940-1574
DOI:10.1177/000331978403500706