Antihistamine Toxicity in Children

Five instances of antihistamine toxicity in children, one resulting in death, are reported here. Three cases were caused by accidental ingestions and two were caused by physician-prescribed overdoses. Initial symptoms and clinical course are far from constant. Control of toxic central-nervous-system...

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Bibliographic Details
Published in:Clinical pediatrics 1969-05, Vol.8 (5), p.297-299
Main Authors: Reyes-Jacang, Amelia, Wenzl, James E.
Format: Article
Language:English
Subjects:
Adolescent
Central Nervous System - drug effects
Child
Child, Preschool
Epilepsy, Tonic-Clonic - chemically induced
Female
Histamine H1 Antagonists - poisoning
Humans
Hyperkinesis - chemically induced
Infant
Male
Medication Errors
Psychoses, Substance-Induced
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Summary:Five instances of antihistamine toxicity in children, one resulting in death, are reported here. Three cases were caused by accidental ingestions and two were caused by physician-prescribed overdoses. Initial symptoms and clinical course are far from constant. Control of toxic central-nervous-system symptoms by sedation or anticonvulsive drugs is a cardinal part of treatment. Stimulants or even mechanical respiratory devices may be needed later for management of postconvulsive depressive states.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992286900800517