Rickets Secondary to Phosphate Depletion: A Sequela of Antacid Use in Infancy

Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis rel...

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Bibliographic Details
Published in:Clinical pediatrics 1995-02, Vol.34 (2), p.73-78
Main Authors: Pivnick, Enikö K., Kerr, Natalie C., Kaufman, Robert A., Jones, Deborah P., Chesney, Russell W.
Format: Article
Language:English
Subjects:
Aluminum Hydroxide - adverse effects
Antacids - adverse effects
Colic - drug therapy
Drug Combinations
Female
Humans
Infant
Intestinal Absorption - drug effects
Magnesium Hydroxide - adverse effects
Osteomalacia - chemically induced
Osteomalacia - diagnostic imaging
Phosphates - deficiency
Phosphates - pharmacokinetics
Radiography
Rickets - chemically induced
Rickets - diagnostic imaging
Simethicone - adverse effects
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Summary:Two infants presented with growth failure and were found to have generalized osteomalacia (rickets) due to phosphate depletion from prolonged administration of an aluminum-containing antacid given for the symptoms of colic. One of the infants developed bilateral proptosis due to craniosynostosis related to the underlying metabolic bone disease. The chronic use of aluminum-containing antacids in infants has potential risk for the growing skeleton and is not innocuous. Therefore, antacid therapy should be used in low doses and very cautiously, with routine monitoring of serum calcium and phosphorus in children taking medications which reduce gastrointestinal phosphate absorption.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992289503400202