Dynamic Optical Contrast Imaging: A Technique to Differentiate Parathyroid Tissue from Surrounding Tissues

The variable location and indistinct features of parathyroid glands can make their intraoperative identification challenging. Currently, there exists no routine use of localization methods during surgery. Dynamic optical contrast imaging (DOCI) leverages a novel realization of temporally dependent m...

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Bibliographic Details
Published in:Otolaryngology-head and neck surgery 2017-03, Vol.156 (3), p.480-483
Main Authors: Kim, Irene A., Taylor, Zachary D., Cheng, Harrison, Sebastian, Christine, Maccabi, Ashkan, Garritano, James, Tajudeen, Bobby, Razfar, Ali, Palma Diaz, Fernando, Yeh, Michael, Stafsudd, Oscar, Grundfest, Warren, St. John, Maie
Format: Article
Language:English
Subjects:
adenoma
hyperplasia
imaging
localization
parathyroid surgery
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Summary:The variable location and indistinct features of parathyroid glands can make their intraoperative identification challenging. Currently, there exists no routine use of localization methods during surgery. Dynamic optical contrast imaging (DOCI) leverages a novel realization of temporally dependent measurements of tissue autofluorescence that allows the acquisition of specific tissue properties. A prospective series of patients with primary hyperparathyroidism was examined. Parathyroid lesions and surrounding tissues were collected; fluorescence decay images were acquired via DOCI. Ex vivo samples (81 patients) were processed for histologic assessment. DOCI extracts relative fluorescence decay information in a surgically relevant field of view with a clinically accessible acquisition time
ISSN:0194-5998
1097-6817
DOI:10.1177/0194599816686294