Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature

Polymorphous hemangioendothelioma is a rare vascular tumor of borderline malignant potential and only 10 cases have been described in the literature so far. We report a case of nodal and extranodal polymorphous hemangioendothelioma and review the literature. A 66-year-old man with an unremarkable pa...

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Bibliographic Details
Published in:Tumori 2009-01, Vol.95 (1), p.94-97
Main Authors: Falleti, Jessica, Siano, Maria, De Cecio, Rossella, Somma, Anna, Pettinato, Guido, Insabato, Luigi
Format: Article
Language:English
Subjects:
Aged
Biopsy, Fine-Needle
Hemangioendothelioma - metabolism
Hemangioendothelioma - pathology
Hemangioendothelioma - therapy
Humans
Immunohistochemistry
Lymph Nodes - pathology
Male
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - therapy
Oral Surgical Procedures
Radiotherapy
Soft Tissue Neoplasms - metabolism
Soft Tissue Neoplasms - pathology
Soft Tissue Neoplasms - therapy
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Summary:Polymorphous hemangioendothelioma is a rare vascular tumor of borderline malignant potential and only 10 cases have been described in the literature so far. We report a case of nodal and extranodal polymorphous hemangioendothelioma and review the literature. A 66-year-old man with an unremarkable past medical history was admitted for a left submandibular mass. The main nodule was composed of angiosarcoma-like areas mixed with angiomatous features; some vascular spaces with hobnail endothelium were seen. The tumor involved two adjacent lymph nodes. Immunohistochemically, the neoplastic cells were strongly positive for CD31 and vimentin. After a few months the tumor recurred and the patient was treated with radiation therapy. Polymorphous hemangioendothelioma is a distinct entity in the hemangioendothelioma group with its own clinical and histological features.
ISSN:0300-8916
2038-2529
DOI:10.1177/030089160909500116