Assessment of chemokine serum levels in epithelial ovarian cancer patients

• Published in: Tumori 2013-07, Vol.99 (4), p.540-544
• Main Authors: Falcão-Júnior, João Oscar Almeida, Teixeira-Carvalho, Andréa, Cândido, Eduardo Batista, Lages, Elisa Lopes, Freitas G, Gustavo Ferreira, Lamaita, Rívia Mara, Bonfim, Lívia Paula Freire, Salera, Rafael Borges, Traiman P, Paulo, da Silva-Filho, Agnaldo Lopes
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biomarkers, Tumor - blood; Carcinoma, Ovarian Epithelial; Chemokine CCL2 - blood; Chemokine CCL3 - blood; Chemokine CCL4 - blood; Chemokine CCL5 - blood; Chemokines - blood; Female; Humans; Interleukin-8 - blood; Middle Aged; Neoplasm Staging; Neoplasms, Glandular and Epithelial - blood; Neoplasms, Glandular and Epithelial - pathology; Neoplasms, Glandular and Epithelial - physiopathology; Ovarian Neoplasms - blood; Ovarian Neoplasms - pathology; Ovarian Neoplasms - physiopathology
• ISSN: 0300-8916; 2038-2529
• DOI: 10.1177/030089161309900417

Aims and background The study was undertaken to investigate CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES and CXCL8/IL-8 women with epithelial ovarian cancer. Methods and study design Sixteen patients diagnosed with epithelial ovarian cancer and 18 healthy women with no evidence of malign neoplasia (control group) aged from 23 to 89 years (mean ± SEM, 58.7 ± 2.3) were included. The epithelial ovarian cancer patients underwent laparotomy and debulking surgery. Chemokines serum levels were measured by cytometric bead array. Statistical analysis was performed using Mann-Whitney and Kendall's tau. P