Plasma bupivacaine concentrations in children during caudal epidural analgesia

Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 microgram/ml were reached, which are well within the limits of projecte...

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Bibliographic Details
Published in:Anaesthesia and intensive care 1983-02, Vol.11 (1), p.20-22
Main Authors: Eyres, R L, Bishop, W, Oppenheim, R C, Brown, T C
Format: Article
Language:English
Subjects:
Age Factors
Anesthesia, Caudal
Arteries
Bupivacaine - administration & dosage
Bupivacaine - blood
Bupivacaine - toxicity
Child
Child, Preschool
Humans
Infant
Injections
Sacrum
Time Factors
Veins
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Summary:Plasma bupivacaine concentrations were measured in 45 children, whose ages ranged from 4 months to 12 years, following administration of caudal epidural analgesia. Using 3 mg/kg of bupivacaine 0.25%, mean blood levels of 1.2-1.4 microgram/ml were reached, which are well within the limits of projected toxic levels. Simultaneous arterial and venous sampling showed a small but significant difference between these two sampling sites fo the first fifteen minutes.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x8301100104