Plasma lignocaine concentrations following topical laryngeal application

Lignocaine 4%, 4 mg/kg, was sprayed onto the larynx and subglottic area of 96 children aged from 2 weeks to 12 years and plasma lignocaine concentrations were measured. While the majority were well within the accepted safe range (4.5 micrograms/ml) occasional concentrations over 8 micrograms/ml appe...

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Bibliographic Details
Published in:Anaesthesia and intensive care 1983-02, Vol.11 (1), p.23-26
Main Authors: Eyres, R L, Bishop, W, Oppenheim, R C, Brown, T C
Format: Article
Language:English
Subjects:
Administration, Topical
Aerosols
Age Factors
Anesthesia, Local
Arteries
Child
Child, Preschool
Humans
Infant
Infant, Newborn
Larynx
Lidocaine - administration & dosage
Lidocaine - blood
Lidocaine - toxicity
Time Factors
Veins
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Summary:Lignocaine 4%, 4 mg/kg, was sprayed onto the larynx and subglottic area of 96 children aged from 2 weeks to 12 years and plasma lignocaine concentrations were measured. While the majority were well within the accepted safe range (4.5 micrograms/ml) occasional concentrations over 8 micrograms/ml appeared in all groups. Simultaneous arterial and venous sampling showed a small but significant difference in the first 10 minutes.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x8301100105