Homocysteine, Vitamin B 12 and Folic Acid Levels in Psoriatic Patients and Correlation with Disease Severity

Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. Th...

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Bibliographic Details
Published in:International journal of immunopathology and pharmacology 2010-07, Vol.23 (3), p.911-916
Main Authors: Brazzelli, V., Grasso, V., Fornara, L., Moggio, E., Gamba, G., Villani, S., Borroni, G.
Format: Article
Language:English
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Summary:Hyperhomocysteinaemia represents an independent risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. Psoriasis is a chronic inflammatory skin disease associated with increased atherothrombosis and cardiovascular risk profile. The aim of this study is to investigate homocysteine, folic acid and vitamin B12 levels in a cohort of psoriatic patients and its relationship with the severity of the disease. A retrospective observational study in 98 patients with chronic plaque psoriasis and 98 healthy controls was performed. Total plasma homocysteine level, folic acid, vitamin B 12 and PASI index were assessed in every patient. Patients with psoriasis had plasma homocysteine levels higher than controls (57% of cases and 25% of controls; p
ISSN:0394-6320
2058-7384
DOI:10.1177/039463201002300327