In Vitro Effect of Copper on the Stromal Cells of Bone Marrow in Rats

The effect of copper in form of copper sulphate (CuSO4 × 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental gr...

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Bibliographic Details
Published in:Toxicology and industrial health 1989-12, Vol.5 (6), p.1117-1123
Main Author: Miszta, Helena
Format: Article
Language:English
Subjects:
Animals
Bone Marrow - drug effects
Bone Marrow Cells
Cell Count
Cells, Cultured
Copper - blood
Copper - toxicity
Erythrocytes - drug effects
Hemoglobins - analysis
Hemoglobins - drug effects
Male
Rats
Rats, Inbred Strains
Time Factors
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Summary:The effect of copper in form of copper sulphate (CuSO4 × 5 H2O) was studied in the bone marrow cells of rats of Wistar strain in an in vitro culture. Evident differences between tissue cultures of the bone marrow cells were observed between the control and experimental groups. In the experimental group, the CFU-F colonies appeared as early as in 3rd day while in the control group in 5th day. Loosely arranged fibroblasts, macrophages and adipocytes also showed quantitative differences between groups. An increase in mean corpuscular hemoglobin (MCH) was also found in periphral blood of experimental animals.
ISSN:0748-2337
1477-0393
DOI:10.1177/074823378900500617