Multi-Route Exposure Assessment and Biological Monitoring of Urban Pesticide Applicators during Structural Control Treatments with Chlorpyrifos

• Published in: Toxicology and industrial health 1990-05, Vol.6 (3-4), p.349-371
• Main Authors: Fenske, Richard A., Elkner, Kenneth P.
• Format: Article
• Language: English
• Subjects: Absorption; Air Pollutants, Occupational - analysis; Chlorpyrifos - pharmacokinetics; Chlorpyrifos - urine; Drug Administration Routes; Humans; Male; Occupational Exposure; Pest Control - methods; Respiratory System - metabolism; Skin Absorption; Urban Health
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/074823379000600301

A preliminary study of dermal and respiratory exposure to chlorpyrifos (DursbanR TC) during structural treatments was conducted with eight workers from a commercial pest control company. The compound was applied by sub-slab and soil injection to four houses, with each application involving two workers. Crawl space applications were included in three of the jobs. Field sampling extended over the entire workday, and included personal air samples and dermal exposure evaluation with patches and handwashes. A fluorescent tracer was added to the formulation for qualitative determination of skin deposition patterns. Pre-exposure and complete 72 hour urine samples were also collected. Total dermal exposure averaged 5.94 mg/hr. The major contributors were the upper legs (38%) and the forearms (34%). Accidents occurred during two of the four applications observed, and the two workers involved in the accidents were the most highly exposed individuals. The mean estimated absorbed daily dose was 9.5 ug/kg/day, with approximately 73% contributed by the dermal route. Thus, under these work conditions the Threshold Limit Value is not an appropriate guide for worker safety. The principal urinary metabolite of chlorpyrifos, 3,5,6-trichloro-2-pyridinol, was found in measurable quantities in all urine samples. Urinary metabolite levels collected 24–48 hr post-exposure were highly correlated (R2 = 0.86) with total absorbed dose estimates. The high variability among individual excretion patterns suggests against the use of urine spot sampling, but longer collections may prove useful in the development of a Biological Exposure Index for chlorpyrifos.