New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/ Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies

New pH and temperature sensitive semi-interpenetrated polymer networks (semi-IPNs) were developed by combining cross-linked PNIPAAm with hyaluronic acid (HA). At pH 7.4, the PNIPAAm/HA semi-IPN hydrogels had significantly greater and faster swelling at 25°C and a more complete deswelling at 37°C tha...

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Bibliographic Details
Published in:Journal of bioactive and compatible polymers 2010-03, Vol.25 (2), p.169-184
Main Authors: Santos, João R., Alves, Natália M., Mano, João F.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Exact sciences and technology
General pharmacology
Medical sciences
Natural polymers
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Properties and characterization
Solution and gel properties
Starch and polysaccharides
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Summary:New pH and temperature sensitive semi-interpenetrated polymer networks (semi-IPNs) were developed by combining cross-linked PNIPAAm with hyaluronic acid (HA). At pH 7.4, the PNIPAAm/HA semi-IPN hydrogels had significantly greater and faster swelling at 25°C and a more complete deswelling at 37°C than PNIPAAm hydrogels. The temperature-dependent reversibility behavior was analyzed for biomaterial applications. Gentamicin was incorporated as a model drug, and the release profile from the hydrogels was followed under physiological conditions. The presence of HA, even in small quantities, allowed a more complete release of the gentamicin from the hydrogel. The PNIPAAm/HA semi-IPN hydrogels respond to both changes in temperature and pH making it suitable as a delivery system for therapeutics.
ISSN:0883-9115
1530-8030
DOI:10.1177/0883911509357863