Mitigation of nitrofurantoin-induced toxicity in the perfused rat lung

• Published in: Human & experimental toxicology 1997-12, Vol.16 (12), p.727-732
• Main Authors: Bernard, Craig E, Magid, Amani A, Benedict Yen, TS, Hoener, Betty-ann
• Format: Article
• Language: English
• Subjects: Animals; Anti-Infective Agents, Urinary - toxicity; Biological and medical sciences; Drug toxicity and drugs side effects treatment; Glutathione - metabolism; In Vitro Techniques; Lung - pathology; Lung Diseases - chemically induced; Lung Diseases - metabolism; Lung Diseases - pathology; Male; Medical sciences; Microscopy, Electron; Nitrofurantoin - toxicity; Oxidative Stress - drug effects; Peptidyl-Dipeptidase A - metabolism; Pharmacology. Drug treatments; Pulmonary Edema - chemically induced; Pulmonary Edema - pathology; Rats; Rats, Sprague-Dawley; Respiratory Function Tests; Sulfhydryl Compounds - metabolism; Toxicity: respiratory system, ent, stomatology; Vitamin E - metabolism; Weight Gain - drug effects
• ISSN: 0960-3271; 1477-0903
• DOI: 10.1177/096032719701601206

1 Nitrofurantoin is an antimicrobial agent which pro duces pulmonary toxicity via the redox cycling of the nitro group and its radical anion. This futile cycling triggers a complex series of events known collectively as oxidative stress. 2 In the isolated perfused rat lung, nitrofurantoin induced a decrease in tissue levels of glutathione but not protein thiols by the end of the 180 min experi ment. There was no decline in tissue levels of angiotensin converting enzyme (a marker of cell disruption). However, edema was extensive as mon itored in real time by weight gain (2.71 ± 0.56 g vs 0.63 ± 0.53 g in control, P