Urinary cadmium as indicator of renal cadmium in humans: an autopsy study

Objective: To estimate the equivalent cadmium levels in renal cortex and in urine, as based on autopsy analysis of subjects not exposed to cadmium occupationally. Methods: The levels of Cd were determined in renal cortex, liver, urine and urinary bladder of 39 subjects deceased at the age 42+14 year...

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Bibliographic Details
Published in:Human & experimental toxicology 1998-06, Vol.17 (6), p.302-306
Main Authors: Orlowski, Czeslaw, Piotrowski, Jerzy K, Subdys, Joanna K, Gross, Adam
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Cadmium - analysis
Cadmium - urine
Chemical and industrial products toxicology. Toxic occupational diseases
Child
Creatinine - analysis
Environmental Monitoring
Female
Humans
Kidney Cortex - chemistry
Kidney Cortex - metabolism
Liver - chemistry
Liver - metabolism
Male
Medical sciences
Metals and various inorganic compounds
Middle Aged
Proteinuria
Spectrophotometry, Atomic
Toxicology
Urinary Bladder - chemistry
Urinary Bladder - metabolism
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Summary:Objective: To estimate the equivalent cadmium levels in renal cortex and in urine, as based on autopsy analysis of subjects not exposed to cadmium occupationally. Methods: The levels of Cd were determined in renal cortex, liver, urine and urinary bladder of 39 subjects deceased at the age 42+14 years. Flame atomic absorption spectrometry (kidneys, liver) and flameless AAS (urine, bladder) were used. Results: The urinary cadmium level determined post mortem is strongly correlated with the renal Cd levels. Eliminating cases with high urinary proteins and extrapolating from sets of data with elevated urinary protein concentration to its normal range yielded a value of 1.7 mg/g creatinine as equivalent to the renal level of 50 mg/g w.w. Conclusions: It seems possible to use monitoring data for cadmium in urine and in renal cortex in a coherent way.
ISSN:0960-3271
1477-0903
DOI:10.1177/096032719801700603