Factors affecting faecal immunochemical test positive rates: demographic, pathological, behavioural and environmental variables

Objectives Positive rates in faecal immunochemical test (FIT)-based colorectal cancer screening programmes vary, suggesting that differences between programmes may affect test results. We examined whether demographic, pathological, behavioural, and environmental factors affected haemoglobin concentr...

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Bibliographic Details
Published in:Journal of medical screening 2015-12, Vol.22 (4), p.187-193
Main Authors: Symonds, Erin L, Osborne, Joanne M, Cole, Stephen R, Bampton, Peter A, Fraser, Robert JL, Young, Graeme P
Format: Article
Language:English
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Summary:Objectives Positive rates in faecal immunochemical test (FIT)-based colorectal cancer screening programmes vary, suggesting that differences between programmes may affect test results. We examined whether demographic, pathological, behavioural, and environmental factors affected haemoglobin concentration and positive rates where samples are mailed. Methods A retrospective cohort study; 34,298 collection devices were sent, over five years, to screening invitees (median age 60.6). Participant demographics, temperature on sample postage day, and previous screening were recorded. Outcomes from colonoscopy performed within a year following FIT were collected. Multivariate logistic regression identified significant predictors of test positivity. Results Higher positive rate was independently associated with male gender, older age, lower socioeconomic status, and distally located neoplasia, and negatively associated with previous screening (p 
ISSN:0969-1413
1475-5793
DOI:10.1177/0969141315584783