Experimentally induced cholangiohepatopathy by dosing sheep with fractionated extracts from Brachiaria decumbens

Department of Veterinary Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Cholangiohepatopathy was induced in 5 lambs by oral administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout the h...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2001-03, Vol.13 (2), p.170-172
Main Authors: Cruz, C, Driemeier, D, Pires, VS, Schenkel, EP
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Animals, Newborn
Biological and medical sciences
Chemical and Drug Induced Liver Injury
Fundamental and applied biological sciences. Psychology
Liver Diseases - pathology
Liver Diseases - veterinary
Microbiology
Panicum
Photosensitivity Disorders - chemically induced
Photosensitivity Disorders - veterinary
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Poaceae
Sheep
Sheep Diseases - pathology
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Summary:Department of Veterinary Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Cholangiohepatopathy was induced in 5 lambs by oral administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout the hepatic parenchyma in 4 lambs. The microscopic changes, which were similar to those produced by other steroidal sapogenins-containing plants such as Tribulus terrestris and Panicum spp., included multifocal cholangitis, bile duct proliferation, and the presence of crystals in the biliary system.
ISSN:1040-6387
1943-4936
DOI:10.1177/104063870101300215