Oxaliplatin-Induced Renal Tubular Vacuolization

Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-ol...

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Bibliographic Details
Published in:The Annals of pharmacotherapy 2014-06, Vol.48 (6), p.796-800
Main Authors: Yaghobi Joybari, Ali, Sarbaz, Samaneh, Azadeh, Payam, Mirafsharieh, S. Abbas, Rahbari, Ali, Farasatinasab, Maryam, Mokhtari, Majid
Format: Article
Language:English
Subjects:
Adenocarcinoma - drug therapy
Adult
Anemias. Hemoglobinopathies
Antineoplastic Agents - adverse effects
Biological and medical sciences
Colonic Neoplasms - drug therapy
Diseases of red blood cells
Female
Hematologic and hematopoietic diseases
Humans
Kidney - pathology
Kidney Diseases - chemically induced
Kidney Diseases - pathology
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Organoplatinum Compounds - adverse effects
Pharmacology. Drug treatments
Platelet diseases and coagulopathies
Renal failure
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Summary:Objective: Chemotherapy with oxaliplatin is used for a wide range of malignancies. Unlike other platinum derivatives, oxaliplatin has less nephrotoxicity. However, in recent years, there have been multiple reports of different forms of renal toxicity related to this agent. Case Summary: A 40-year-old woman with colon adenocarcinoma developed jaundice, hematuria, and oliguria after the 36th cycle of oxaliplatin chemotherapy. Laboratory data revealed severe anemia, thrombocytopenia, increased creatinine, indirect hyperbilirubinemia, and high lactate dehydrogenase. A negative direct antiglobulin test and presence of
ISSN:1060-0280
1542-6270
DOI:10.1177/1060028014526160