Factors Associated With Acute Kidney Injury in Children Receiving Vancomycin

Background: As higher vancomycin doses have been used in children, concern for acute kidney injury (AKI) has increased. Data describing factors associated with AKI, particularly dose-related factors, are limited. Objective: To determine the incidence of AKI in children receiving intravenous vancomyc...

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Bibliographic Details
Published in:The Annals of pharmacotherapy 2014-12, Vol.48 (12), p.1555-1562
Main Authors: Sinclair, Elizabeth A., Yenokyan, Gayane, McMunn, Andrea, Fadrowski, Jeffrey J., Milstone, Aaron M., Lee, Carlton K. K.
Format: Article
Language:English
Subjects:
Academic Medical Centers
Acute Kidney Injury - chemically induced
Acute Kidney Injury - epidemiology
Adolescent
Anti-Bacterial Agents - adverse effects
Biological and medical sciences
Child
Child, Preschool
Female
Hospitals, Pediatric
Humans
Incidence
Infant
Kidneys
Male
Medical sciences
Nephrology. Urinary tract diseases
Odds Ratio
Pharmacology. Drug treatments
Retrospective Studies
Risk Factors
Tertiary Care Centers
Urinary system involvement in other diseases. Miscellaneous
Vancomycin - adverse effects
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Summary:Background: As higher vancomycin doses have been used in children, concern for acute kidney injury (AKI) has increased. Data describing factors associated with AKI, particularly dose-related factors, are limited. Objective: To determine the incidence of AKI in children receiving intravenous vancomycin and to identify factors associated with increased odds of AKI. Methods: A retrospective review of patients admitted to a tertiary academic pediatric hospital from February 2009 to September 2010 was performed. Patients 3 months to
ISSN:1060-0280
1542-6270
DOI:10.1177/1060028014549185