Conversion From Continuous Infusion Fentanyl to Continuous Infusion Hydromorphone in the Pediatric Intensive Care Unit

Background: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children. Objective: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg h...

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Bibliographic Details
Published in:The Annals of pharmacotherapy 2021-12, Vol.55 (12), p.1439-1446
Main Authors: Harkin, Maura, Miller, Jamie L., Lim, Sin Yin, Neely, Stephen B., Walsh, Christina K., Johnson, Peter N.
Format: Article
Language:English
Subjects:
Adolescent
Analgesics, Opioid - adverse effects
Child
Fentanyl
Humans
Hydromorphone
Intensive Care Units, Pediatric
Retrospective Studies
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Summary:Background: Opioid rotations from fentanyl to hydromorphone may reduce opioid/sedative exposure in critically ill children. Objective: The primary objective was to determine the conversion percentage from fentanyl to hydromorphone infusions using equianalgesic conversions (0.1 mg fentanyl = 1.5 mg hydromorphone). Secondary objectives included identification of the median time and hydromorphone rate at stabilization (defined as the first 24-hour period no hydromorphone rates changed, 80% of State Behavioral Scale [SBS] scores between 0 and −1, and
ISSN:1060-0280
1542-6270
DOI:10.1177/10600280211003170