Vericiguat: A Novel Oral Soluble Guanylate Cyclase Stimulator for the Treatment of Heart Failure

• Published in: Annals of Pharmacotherapy 2022-05, Vol.56 (5), p.600-608
• Main Authors: Campbell, Nicole, Kalabalik-Hoganson, Julie, Frey, Kathleen
• Format: Article
• Language: English
• Subjects: Chronic Disease; Clinical Trials, Phase III as Topic; Heart Failure - drug therapy; Heterocyclic Compounds, 2-Ring - adverse effects; Hospitalization; Humans; Pyrimidines - adverse effects; Soluble Guanylyl Cyclase - therapeutic use; Stroke Volume; Vasodilator Agents - therapeutic use
• ISSN: 1060-0280; 1542-6270
• DOI: 10.1177/10600280211041384

Objective To review the efficacy and safety of vericiguat indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following hospitalization or need for outpatient intravenous diuretics in adult patients with chronic symptomatic HF and ejection fraction (EF) less than 45%. Data Sources A literature search through MEDLINE with search terms MK1242, BAY 1021189, and vericiguat was conducted. Product labeling and English-language studies assessing pharmacokinetics, pharmacodynamics, efficacy, or safety of vericiguat were included. Study Selection and Data Extraction Preclinical and clinical studies describing the efficacy and safety of vericiguat were included. Data Synthesis The phase 3 VICTORIA clinical trial demonstrated a lower composite primary outcome of death from cardiovascular causes or first hospitalization in the vericiguat group compared to placebo. Total hospitalizations for HF in the vericiguat group were significantly less compared to placebo. The composite secondary outcome of death from any cause or first HF hospitalization was significantly less in the vericiguat group. Relevance to Patient Care and Clinical Practice The addition of vericiguat offers a new treatment option for those in whom rehospitalization or recurrent outpatient intravenous diuretic treatment is a concern. Given high rates of nonadherence in HF patients, vericiguat represents an additional treatment option, especially for patients who do not tolerate available HF therapies. Conclusion Vericiguat is a novel soluble guanylate cyclase stimulator that is safe and effective for reducing the risk of cardiovascular death and HF hospitalization in adults with symptomatic chronic HF and reduced EF.