Rapid development of band keratopathy of corneal graft associated with treatment with intracameral recombinant tissue plasminogen activator for postoperative fibrin reaction

To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction. In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract. A dense band keratopa...

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Bibliographic Details
Published in:European journal of ophthalmology 2007-05, Vol.17 (3), p.433-436
Main Authors: Spitzer, M S, Szurman, P, Aisenbrey, S, Rohrbach, J M
Format: Article
Language:English
Subjects:
Aged
Calcinosis - chemically induced
Calcinosis - diagnosis
Cataract Extraction
Corneal Diseases - chemically induced
Corneal Diseases - diagnosis
Corneal Ulcer - surgery
Fibrin - drug effects
Fibrinolytic Agents - adverse effects
Humans
Keratoplasty, Penetrating
Male
Postoperative Complications
Recombinant Proteins - adverse effects
Tissue Plasminogen Activator - adverse effects
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Summary:To report a corneal transplant complication associated with intracameral recombinant tissue plasminogen activator (rTPA) treatment of postoperative fibrin reaction. In a 71-year-old patient, a triple procedure was performed for perforated rheumatic ulcer and secondary cataract. A dense band keratopathy developed rapidly within 36 hours after the use of intracameral injection of rTPA for the treatment of a dense fibrin clot. This is the first report of rapid development of massive band keratopathy in a corneal graft after triple procedure and treatment with intracameral rTPA. Intracameral rTPA should be used with caution in patients with attenuated endothelium.
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210701700328