Is multifocal ERG a reliable index of macular function after triamcinolone acetonide injection in diffuse diabetic macular edema?

To investigate the changes and the reliability of multifocal electroretinogram (mfERG) after intravitreal triamcinolone acetonide (IVTA) injection in diffuse diabetic macular edema (DDME). Twenty-four eyes with DDME were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. Visu...

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Bibliographic Details
Published in:European journal of ophthalmology 2009-11, Vol.19 (6), p.1017-1027
Main Authors: Durukan, Ali Hakan, Memisoglu, Serdar, Gundogan, Fatih Cakir
Format: Article
Language:English
Subjects:
Adult
Aged
Diabetic Retinopathy - drug therapy
Diabetic Retinopathy - physiopathology
Electroretinography
Female
Glucocorticoids - administration & dosage
Humans
Injections
Macula Lutea - physiology
Macular Edema - drug therapy
Macular Edema - physiopathology
Male
Middle Aged
Reproducibility of Results
Tomography, Optical Coherence
Triamcinolone Acetonide - administration & dosage
Visual Acuity - physiology
Vitreous Body
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Summary:To investigate the changes and the reliability of multifocal electroretinogram (mfERG) after intravitreal triamcinolone acetonide (IVTA) injection in diffuse diabetic macular edema (DDME). Twenty-four eyes with DDME were treated with an intravitreal injection of 4 mg of triamcinolone acetonide. Visual acuity (VA), central macular thickness (CMT), mfERG, and intraocular pressures (IOP) were evaluated in the preinjection period and the 15th day, third month, and sixth month after IVTA injection. Age and gender of the patients were not significantly correlated to logMAR VA (p=0.888 for age, p=0.192 for gender), CMT (p=0.282 for age, p=0.625 for gender), or P1/N1 amplitudes/implicit times in mfERG at baseline (p>0.05 for age and gender). The correlation between logMAR VA and CMT at baseline also was not significant (r=0.069, p=0.750). The VA increased significantly at the 15th day (p0.05 for all). The positive effect of IVTA injection in DDME is reversible until the sixth month. Monitoring of the improvement in visual function by mfERG is violated possibly by irreversible macular dysfunction due to long duration of macular edema and primary neurophysiologic effects of diabetes on the retina.
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210901900619