Topical tacrolimus in high-risk corneal transplants

• Published in: European journal of ophthalmology 2024-01, Vol.34 (1), p.140-145
• Main Authors: Bernardes, Luís, Gil, João, Costa, Esmeralda, Tavares, Cristina, Rosa, Andreia, Quadrado, Maria João, Murta, Joaquim
• Format: Article
• Language: English
• ISSN: 1120-6721; 1724-6016
• DOI: 10.1177/11206721231172236

Purpose The purpose of this study was to assess the use of topical tacrolimus ointment in preventing rejection in high-risk corneal grafts, when added to the standard immunosuppressive regimen. Methods We conducted an observational, retrospective study using clinical data of high-risk patients subjected to penetrating keratoplasty, who were treated with topical tacrolimus ointment 0.2 mg/g twice a day plus topical dexamethasone 0.1 mg/ml 6 id and compared it with a similar control group treated with topical dexamethasone 0.1 mg/ml 6 id alone. High-risk status was attributed to patients with previous ipsilateral corneal graft failure, two or more quadrants with corneal neovascularization or an infectious or inflammatory corneal disease. Results We analysed 53 patients in the trial group versus 53 patients in the control group, with similar age, baseline diagnosis and risk factors, and median follow-up times of 30 and and 24 months, respectively. Survival analysis showed a higher graft survival rate at all follow-up periods for patients treated with topical tacrolimus (p