Prevalence and clinical implications of insertions in the HIV-1 p6 Gag N-terminal region in drug-naive individuals initiating antiretroviral therapy

We assessed the prevalence and clinical impact of insertions within the HIV-1 p6 Gag proline-rich (PTAP) region on initial antiretroviral therapy response in 461 HIV-infected, drug-naive individuals initiating therapy in British Columbia, Canada between June 1996 and August 1998. HIV p6 Gag insertio...

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Bibliographic Details
Published in:Antiviral therapy 2003-02, Vol.8 (2), p.91-96
Main Authors: Brumme, Zabrina L, Chan, Keith J, Dong, Winnie WY, Wynhoven, Brian, Mo, Theresa, Hogg, Robert S, Montaner, Julio SG, O'Shaughnessy, Michael V, Harrigan, P Richard
Format: Article
Language:English
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Summary:We assessed the prevalence and clinical impact of insertions within the HIV-1 p6 Gag proline-rich (PTAP) region on initial antiretroviral therapy response in 461 HIV-infected, drug-naive individuals initiating therapy in British Columbia, Canada between June 1996 and August 1998. HIV p6 Gag insertions were detected by nested RT-PCR of extracted patient plasma followed by direct DNA sequencing. Insertions were observed in 70 of 423 successfully genotyped samples (16.5%). HIV p6 Gag insertions were significantly associated with a lower baseline CD4 cell count (P
ISSN:1359-6535
2040-2058
DOI:10.1177/135965350300800202