Chemokines as markers for parasite-induced inflammation and tumors

Chemokines are a group of small secreted proteins (8-10 kDa) produced and released by a wide variety of cell types. They were originally described as mediators of leukocyte recruitment, which is essential in acute and chronic inflammation. They also play a critical role in many pathophysiological pr...

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Bibliographic Details
Published in:The International journal of biological markers 2005-10, Vol.20 (4), p.197-203
Main Authors: TRAKATELLI, C, FRYDAS, S, SALINI, V, CONTI, P, KEMPURAJ, D, VECCHIET, J, HATZISTILIANOU, M, PAPADOPOULOS, E, SIMEONIDOU, I, FOUNTA, A, PALUDI, D, PETRARCA, C, CASTELLANI, M. L, PAPAIOANNOU, N
Format: Article
Language:English
Subjects:
Analytical, structural and metabolic biochemistry
Animals
Biological and medical sciences
Biomarkers - blood
Chemokines - blood
Chemokines - classification
Fundamental and applied biological sciences. Psychology
Humans
Inflammation - blood
Inflammation - parasitology
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Neoplasms - blood
Parasitic Diseases - blood
Parasitic Diseases - parasitology
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Summary:Chemokines are a group of small secreted proteins (8-10 kDa) produced and released by a wide variety of cell types. They were originally described as mediators of leukocyte recruitment, which is essential in acute and chronic inflammation. They also play a critical role in many pathophysiological processes such as allergic responses, infections and autoimmune diseases, tumor growth and hematopoietic development. This review introduces the three supergene families of chemokines (CXC, CC and C) with emphasis on their important role in different states in humans and in animal models with parasitic diseases. The concentration of transcription and translation of the cytokines and chemokines in the parasitic diseases may be an important marker for evaluation of the inflammatory state.
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080502000401