Reaction of Carbon Disulfide with Cyanoacetic Acid Hydrazide: Novel Synthesis of Thiazole and Thiazolo[4,5- c ]pyrazole

The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.

Saved in:
Bibliographic Details
Published in:Journal of chemical research 1999-01, Vol.23 (1), p.10-11
Main Authors: Mohareb, Rafat M., Aziz, Suzan I., Abdel-Sayed, Nadia I., El-Banna, Ahmed H.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reaction of cyanoacetic acid hydrazide with carbon disulfide in basic dimethylformamide afforded the potassium thiocarbamate 2 which underwent ready heterocyclization upon its reaction with α-haloketones to give the thiazole derivatives 4 and 23.
ISSN:1747-5198
2047-6507
DOI:10.1177/174751989902300111