Palladium-catalysed Heteroannulation with Acetylenic Carbinols: Synthesis of 3-Acylmethylisoindolin-1-ones

Palladium-catalysed reactions of 2-iodobenzamides 1–6 with acetylenic carbinols 7–12 having a terminal acetylenic group and an adjacent carbinol functionality result in the formation of the 3-acylmethylisoindolin-1-ones 13–23 in one step.

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Bibliographic Details
Published in:Journal of chemical research 1999-08, Vol.23 (8), p.460-461
Main Authors: Kundu, Nitya G., Khan, M. Wahab, Mahanty, Jyan S.
Format: Article
Language:English
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Summary:Palladium-catalysed reactions of 2-iodobenzamides 1–6 with acetylenic carbinols 7–12 having a terminal acetylenic group and an adjacent carbinol functionality result in the formation of the 3-acylmethylisoindolin-1-ones 13–23 in one step.
ISSN:1747-5198
2047-6507
DOI:10.1177/174751989902300803