Beneficial role of vitamin D 3 in the prevention of certain respiratory diseases

• Published in: Therapeutic advances in respiratory disease 2013-12, Vol.7 (6), p.327-350
• Main Authors: Lương, Khanh vinh quốc, Nguyễn, Lan Thi Hoàng
• Format: Article
• Language: English
• ISSN: 1753-4666; 1753-4666
• DOI: 10.1177/1753465813503029

There is evidence of aberrations in the vitamin D–endocrine system in subjects with respiratory diseases. Vitamin D deficiency is highly prevalent in patients with respiratory diseases, and patients who receive vitamin D have significantly larger improvements in inspiratory muscle strength and maximal oxygen uptake. Studies have provided an opportunity to determine which proteins link vitamin D to respiratory pathology, including the major histocompatibility complex class II molecules, vitamin D receptor, vitamin D-binding protein, chromosome P 450 , Toll-like receptors, poly(ADP-ribose) polymerase-1, and the reduced form of nicotinamide adenine dinucleotide phosphate. Vitamin D also exerts its effect on respiratory diseases through cell signaling mechanisms, including matrix metalloproteinases, mitogen-activated protein kinase pathways, the Wnt/β-catenin signaling pathway, prostaglandins, reactive oxygen species, and nitric oxide synthase. In conclusion, vitamin D plays a significant role in respiratory diseases. The best form of vitamin D for use in the treatment of respiratory diseases is calcitriol because it is the active metabolite of vitamin D 3 and modulates inflammatory cytokine expression. Further investigation of calcitriol in respiratory diseases is needed.