Anti-Müllerian Hormone and Assessment of Ovarian Reserve After Ovarian Toxic Treatment: A Systematic Narrative Review

Since serum anti-Müllerian hormone (AMH) levels enable quantitative evaluation of ovarian damage, we conducted a computer-based search, using key words, of all articles published in English through the PubMed database from inception until September 2013 to summarize available studies evaluating ovar...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2015-05, Vol.22 (5), p.519-526
Main Authors: Iwase, Akira, Nakamura, Tomoko, Nakahara, Tatsuo, Goto, Maki, Kikkawa, Fumitaka
Format: Article
Language:English
Subjects:
Anti-Mullerian Hormone - blood
Antineoplastic Agents - adverse effects
Biomarkers - blood
Down-Regulation
Embryology
Female
Fertility Preservation
Humans
Infertility, Female - blood
Infertility, Female - chemically induced
Infertility, Female - physiopathology
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Ovarian Reserve - drug effects
Ovarian Reserve - radiation effects
Ovary - drug effects
Ovary - metabolism
Ovary - pathology
Ovary - physiopathology
Predictive Value of Tests
Radiation Injuries - blood
Radiation Injuries - etiology
Radiation Injuries - physiopathology
Radiotherapy - adverse effects
Reproductive Medicine
Review
Risk Factors
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Summary:Since serum anti-Müllerian hormone (AMH) levels enable quantitative evaluation of ovarian damage, we conducted a computer-based search, using key words, of all articles published in English through the PubMed database from inception until September 2013 to summarize available studies evaluating ovarian reserve after ovarian toxic interventions to discuss the usefulness of serum AMH levels. We found that most of the studies demonstrated a decline in serum AMH levels when compared to control or pretreatment levels, with levels dependent on the type of treatment modality. Measurement of serum AMH levels enables quantitative evaluation of ovarian damage caused by ovarian toxic interventions, such as chemotherapy and radiotherapy, instead of qualitative evaluation using menstrual condition or basal follicle-stimulating hormone levels. Serum AMH levels are becoming indispensable to assess the ovarian reserve of patients who desire preservation of ovarian function for fertility and endogenous sex steroid hormones.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719114549856