Acetylenic Terrestrial Anticancer Agents

Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. This review presents 139 active acetylenic molecules of plant, fungal, and soil bacterial origin that reveal cytotoxic and/or anticancer activit...

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Bibliographic Details
Published in:Natural Product Communications 2006-05, Vol.1 (5)
Main Authors: Dembitsky, Valery M, Levitsky, Dmitri O
Format: Article
Language:English
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Summary:Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. This review presents 139 active acetylenic molecules of plant, fungal, and soil bacterial origin that reveal cytotoxic and/or anticancer activities. Although many compounds of this group possess encouraging characteristics, they have never been evaluated as potential anticancer agents. They are of great interest, especially for the medicine and/or pharmaceutical industries. Here we describe structures and biological activities of acetylenic metabolites.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0600100512