Smooth Muscle Relaxant Triterpenoid Glycosides from Rubus idaeus (Raspberry) Leaves

A methanol extract of Rubus idaeus leaves had a relaxant activity on transmurally stimulated Guinea pig ileum preparations in vitro. The extract, when fractionated by column chromatography, yielded two distinct bands with pharmacological activity. After extensive column and preparative TLC separatio...

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Bibliographic Details
Published in:Natural product communications 2006-09, Vol.1 (9)
Main Authors: Vera, Janne Rojas, Dacke, Christopher G., Blunden, Gerald, Patel, Asmita V.
Format: Article
Language:English
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Summary:A methanol extract of Rubus idaeus leaves had a relaxant activity on transmurally stimulated Guinea pig ileum preparations in vitro. The extract, when fractionated by column chromatography, yielded two distinct bands with pharmacological activity. After extensive column and preparative TLC separation, several compounds with smooth muscle relaxant properties were obtained. From band two, three triterpenoid glycosides were characterized, which had significant muscle relaxant activity. From spectroscopic and spectrometric data, these were identified as 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-triol (TG1); 28-(O-β-D-glucopyranosyl)-urs-12-ene-2α, 3β, 19α-trihydroxy-28-oic acid (TG2); and 3β-(O-β-D-glucopyranosyl)-olean-12-ene-1α, 2α, 3β-trihydroxy-28-oic acid (TG3). To the best of our knowledge, TG1 and TG3 are novel compounds.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0600100902