Analgesic Properties of New Pyrrolidinomorphinane Derivatives: Revealing Potential Pathways

The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine e...

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Bibliographic Details
Published in:Natural product communications 2008-10, Vol.3 (10)
Main Authors: Morozova, Ekaterina A., Tolstikova, Tatiana G., Bolkunov, Alexey V., Dolgikh, Margarita P., Shul'ts, Elvira E.
Format: Article
Language:English
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Summary:The pyrrolidinomorphinane derivatives have been found to be active in the writhing tests in mice with the analgesic effect being antagonized by naloxone. This suggests that analgesia is mediated by the opioid system. The compounds also displayed anti-inflammatory activity in formalin and histamine edema experimental models and the data may be evidence for anti-inflammatory activity involvement in the inhibition of pain reaction.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0800301008