(-)-Sclerotiorin from an Unidentified Marine Fungus as an Anti-meiotic and Antifungal Agent

(-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 μM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces Cerevisiae, Asper...

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Bibliographic Details
Published in:Natural product communications 2010-11, Vol.5 (11)
Main Authors: Bao, Li, Xu, Zhenyu, Niu, Shu-bin, Namikoshi, Michio, Kobayashi, Hisayoshi, Liu, Hong-wei
Format: Article
Language:English
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Summary:(-)-Sclerotiorin, isolated and purified from the fermented broth of an unidentified marine fungus (98F134), inhibited the maturation of starfish oocytes induced by 1-methyl adenine with an IC50 value of 0.50 μM. (-)-Sclerotiorin also showed antifungal activity against Saccharomyces Cerevisiae, Aspergilus Fumigatus, Alternaria Longipes, Piricularia Oryzae, Verticillium Albo-Atrum, Fusarium Culmorum, and F. nivale with IC50 values less than 20 μg/mL.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1000501119