Cytotoxic Constituents of Mallotus Microcarpus

A new 3-methoxybenzensulfonic acid 4-O-β-D-glucopyranoside (1), and ten known compounds (2–11) were isolated from the methanolic extract of the stems of Mallotus microcarpus. The cytotoxicity of the isolated compounds was evaluated by the MTT method. 3-Methoxybenzensulfonic acid 4-O-β-D-glucopyranos...

Full description

Saved in:
Bibliographic Details
Published in:Natural product communications 2017-03, Vol.12 (3)
Main Authors: Thai, Tran Huy, Hai, Nguyen Thi, Hien, Nguyen Thi, Ha, Chu Thị Thu, Cuong, Nguyen The, Binh, Pham Thanh, Dang, Nguyen Hai, Dat, Nguyen Tien
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new 3-methoxybenzensulfonic acid 4-O-β-D-glucopyranoside (1), and ten known compounds (2–11) were isolated from the methanolic extract of the stems of Mallotus microcarpus. The cytotoxicity of the isolated compounds was evaluated by the MTT method. 3-Methoxybenzensulfonic acid 4-O-β-D-glucopyranoside (1) and methyl salicylate 2-rutinoside (5) showed strong cytotoxicity against EGFR-TKI-resistant human lung cancer A549 cells in comparison with camptothecin. Compound 1, leonuriside A (2), 3,4'-dihydroxypropiophenone 3-O-glucoside (6) and (1R,2S)-hovetrichoside A (10) inhibited the growth of human breast cancer MCF-7 cell line with IC50 values in the range of 0.48–1.78 μM. This is the first report on the chemical composition and cytotoxic activity of M. microcarpus.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1701200325