Cytotoxic Prenylated Polyphenolic Compounds from Maackia amurensis Root Bark

Two new prenylated flavanones, isomaackiaflavanone A (1), isomaackiaflavanone B (2) and a new prenylated stilbene maackiastilbene (3), along with five known flavanones were isolated from the root bark of Maackia amurensis using repeated column chromatography on silica gel, Sephadex LH-20 and octadec...

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Bibliographic Details
Published in:Natural product communications 2017-07, Vol.12 (7)
Main Authors: Veselova, Marina V., Fedoreyev, Sergey A., Tarbeeva, Darya V., Kulesh, Nadezda I., Kalinovskiy, Anatoliy I., Kuzmich, Aleksandra S., Kim, Natalia Y., Grigorchuk, Valeria P.
Format: Article
Language:English
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Summary:Two new prenylated flavanones, isomaackiaflavanone A (1), isomaackiaflavanone B (2) and a new prenylated stilbene maackiastilbene (3), along with five known flavanones were isolated from the root bark of Maackia amurensis using repeated column chromatography on silica gel, Sephadex LH-20 and octadecyl silica (ODS-A) sorbents. The structures of the new compounds were elucidated by HPLC–PDA–MS, HR-ESI-MS, 1H, 13C, 1H–1H COSY, HSQC, ROESY and HMBC NMR analyses. The cytotoxicity of compounds 1–2, 4–8 against two human cancer cell lines HeLa and SK-MEL-5 was tested using the MTS method. Compounds 4, 6 and 8 showed the strongest cytotoxic activity among the compounds tested with IC50 values of 6.5, 8.8 and 7.7 μM, against SK-MEL-5 cells and 8.2, 18.8 and 12 μM against HeLa cells, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1701200709