New Acetylated Terpenoids from Sponge Rhabdastrella providentiae Inhibit NO Production in LPS Stimulated BV2 Cells

Three new acetylated terpenoids, rhabdaprovidines A-C (1-3), were isolated from the Vietnamese sponge Rhabdastrella providentiae. Their chemical structures were established by HR-ESI-MS, 1D and 2D-NMR experiments. These compounds share 6,6,5-tricyclic nucleus of isomalabaricane-type triterpene, the...

Full description

Saved in:
Bibliographic Details
Published in:Natural product communications 2018-06, Vol.13 (6)
Main Authors: Dung, Duong Thi, Yen, Pham Hai, Nhiem, Nguyen Xuan, Quang, Tran Hong, Tai, Bui Huu, Van Minh, Chau, Kim, Dong Cheol, Oh, Hyuncheol, Kim, Youn Chul, Van Kiem, Phan
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three new acetylated terpenoids, rhabdaprovidines A-C (1-3), were isolated from the Vietnamese sponge Rhabdastrella providentiae. Their chemical structures were established by HR-ESI-MS, 1D and 2D-NMR experiments. These compounds share 6,6,5-tricyclic nucleus of isomalabaricane-type triterpene, the specific secondary constituents from Rhabdastrella species. Compounds 1-3 inhibited NO production in LPS stimulated BV2 cells with IC50 values of 20.4 ± 1.5, 17.5 ± 0.9, and 46.8 ± 2.3 μM, respectively.
ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X1801300602